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KMID : 1001020030010010078
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Journal of Urologic Oncology
2003 Volume.1 No. 1 p.78 ~ p.85
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Expression and Mutation of E-cadherin and β-catenin in Transitional Cell Carcinoma of the Urinary Bladder
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Oh Mee-Hye
Lin Zhen-Hua
Kim Young-Sik
Kim In-Sun
Kim Han-Kyeom
Park Hong-Seok
Cheon Jun
Cho Seong-Jin
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Abstract
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E-cadherin, a cell adhesion molecule that plays a diverse role in cell-cell interaction, and this adhesion is mediated by a group of cytoplasmic proteins, including the catenins that link the E-cadherin to the actin cytoskeleton. They are essential for maintaining epithelial intercellular adhesion and act particularly as a suppressor of invasive ability of cancer. To determine the potential prognostic values of E-cadherin and β-catenin, the correlation with the histologic grade, clinical stage, and tumor recurrence were evaluated and their expression and somatic mutation of 43 patients with transitional cell carcinoma of the urinary bladder. Abnormal immunohistochemical expression of E-cadherin and β-catenin was observed in 14 cases (33%) and 18 cases (42%), respectively of transional cell carcinomas and it was correlated with histologic grade and tumor depth and showed without significance lymph node metastasis. The mutation was seen in only 4 cases (9%) for E-cadherin and none for β-catenin. It was concluded assessment of E-cadherin and β-catenin immunoreactivity may be a useful prognostic factor in transitional cell carcinoma of urinary bladder, but their mutation seems to have a minor role in carcinogenesis.
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KEYWORD
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E-cadherin, β-catenin, Transitional cell carcinoma, Urinary bladder, Prognostic factor
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